diff --git a/lib/internal/webstreams/adapters.js b/lib/internal/webstreams/adapters.js
index 6c2be59a24a..307c3f537ec 100644
--- a/lib/internal/webstreams/adapters.js
+++ b/lib/internal/webstreams/adapters.js
@@ -459,6 +459,7 @@ function newReadableStreamFromStreamReadable(streamReadable, options = kEmptyObj
   const strategy = evaluateStrategyOrFallback(options?.strategy);
 
   let controller;
+  let wasCanceled = false;
 
   function onData(chunk) {
     // Copy the Buffer to detach it from the pool.
@@ -480,6 +481,10 @@ function newReadableStreamFromStreamReadable(streamReadable, options = kEmptyObj
     streamReadable.on('error', () => {});
     if (error)
       return controller.error(error);
+    // Was already canceled
+    if (wasCanceled) {
+      return;
+    }
     controller.close();
   });
 
@@ -491,6 +496,7 @@ function newReadableStreamFromStreamReadable(streamReadable, options = kEmptyObj
     pull() { streamReadable.resume(); },
 
     cancel(reason) {
+      wasCanceled = true;
       destroy(streamReadable, reason);
     },
   }, strategy);
diff --git a/test/parallel/test-stream-readable-from-web-termination.js b/test/parallel/test-stream-readable-from-web-termination.js
new file mode 100644
index 00000000000..68ed7d69694
--- /dev/null
+++ b/test/parallel/test-stream-readable-from-web-termination.js
@@ -0,0 +1,15 @@
+'use strict';
+require('../common');
+const { Readable } = require('stream');
+
+{
+  const r = Readable.from(['data']);
+
+  const wrapper = Readable.fromWeb(Readable.toWeb(r));
+
+  wrapper.on('data', () => {
+    // Destroying wrapper while emitting data should not cause uncaught
+    // exceptions
+    wrapper.destroy();
+  });
+}
diff --git a/test/parallel/test-stream-readable-to-web-termination.js b/test/parallel/test-stream-readable-to-web-termination.js
new file mode 100644
index 00000000000..13fce9bc715
--- /dev/null
+++ b/test/parallel/test-stream-readable-to-web-termination.js
@@ -0,0 +1,12 @@
+'use strict';
+require('../common');
+const { Readable } = require('stream');
+
+{
+  const r = Readable.from([]);
+  // Cancelling reader while closing should not cause uncaught exceptions
+  r.on('close', () => reader.cancel());
+
+  const reader = Readable.toWeb(r).getReader();
+  reader.read();
+}